Effects of Aloe vera on the Regulation of Thyroxine Release in FRTL-5 Thyroid Cells

To determine whether Aloe vera (AV), a traditional herbal medicine, could maintain homeostasis, we investigated its ability to regulate the production of hormones, particularly thyroid hormones. T4 ELISA assay with (6H media) and without thyrotropin (TSH) (5H showed that AV functions endocrine homeostasis. understand mechanisms by which regulates thyroxine release, confirmed protein expression key upstream factors hormone synthesis, such as phosphorylated extracellular signal-regulated kinase (ERK), cAMP response element binding (CREB), B (p-Akt). Although ERK CREB were decreased in 6H media, they increased unchanged, respectively, 5H media. However, Akt was not changed both Furthermore, inhibition A (PKA) H89 eliminated AV-induced phosphorylation C (PKC) GF 109203X did eliminate These results suggested has TSH-like activity release through TPO PKA pathways. may function constant level hormones body, be candidate for disease therapies.